If you’re looking to boost your complexion from the inside out – investing in and enhancing your skin’s health on a deeper level, polynucleotides might just be your new favourite treatment.

At Cosmetica London, we’re proud to offer Plinest polynucleotides, one of the most clinically trusted formulations on the market. But what exactly are polynucleotides, and why is everyone talking about them? Let’s delve a little more into this trending treatment.

Polynucleotides – What Are They?

Polynucleotides are purified chains of DNA molecules originally derived from salmon or trout (yes, really – which is where the sensationalised nickname of ‘Salmon Sperm Facials’ came from.) They’re completely biocompatible and highly effective at encouraging your body’s own repair and regeneration processes. When injected into the skin, polynucleotides work by stimulating tissue regeneration, improving hydration and boosting collagen and elastin production; helping restore skin health from the inside out. They’re an excellent option for treating a range of concerns, including:

• Early signs of ageing: such as fine lines and loss of elasticity
• Volume loss and skin thinning: particularly in delicate areas like the under eyes
• Dullness and dehydration
• Inflammation and redness in sensitive or rosacea-prone skin
• Acne scarring and other forms of textural irregularity
• Sun damage and pigmentation irregularities

Polynucleotides don’t freeze or fill, unlike other injectables you may have heard of (think: dermal fillers or Botox… though both these treatments still have their place in the aesthetics arena!) Instead, they’re a regenerative, natural solution for anyone seeking healthier, more resilient skin without injecting volume.

What Do Polynucleotides Do?

Polynucleotides stimulate fibroblast activity (your skin’s repair cells), increase hydration, improve elasticity and promote tissue regeneration – making them a powerful option for restoring skin health, softening fine lines and calming inflammation. Unlike other injectables that are used to add volume or freeze movement, these molecules heal and enhance from within.

Who Are Polynucleotides Suitable For?

Polynucleotides are suitable for most adults experiencing early signs of ageing, dullness, skin laxity or inflammation. They’re especially helpful for those with sensitive or reactive skin, as they help regulate and soothe the skin barrier. They can be used on the face and body.

Where Can Polynucleotides Be Injected?

You can have polynucleotides injected into the face, under eyes, neck, décolletage and even the hands. Basically, anywhere your skin would benefit from a little extra TLC. They’re particularly popular in delicate areas like the under eyes, treating dark circles at the source.

Are Polynucleotides Filler?

No – polynucleotides are not dermal filler. They don’t add volume like dermal fillers… instead, they regenerate tissue over time by improving skin texture, tone and quality.

Which Polynucleotides Do We Use At Cosmetica London?

At Cosmetica London, we’re proud to use Plinest polynucleotides, one of the most respected and widely studied formulations in aesthetic medicine. Plinest products are backed by over 70 scientific papers and have an excellent safety profile; used around the world for many years.

Are Polynucleotides Safe?

Yes, polynucleotides are very safe when administered by trained medical professionals – such as the medical team at Cosmetica London! They are non-crosslinked, biocompatible and metabolised naturally by the body.

Can Polynucleotides Cause A Vascular Occlusion?

Unlike fillers, polynucleotides do not pose a risk of vascular occlusion. They’re not volumising agents and don’t block blood vessels – another reason they’re ideal for use around the eyes.

Can I Have Polynucleotides For Under Eyes?

Absolutely. Polynucleotides are one of the safest and most effective treatments for the under-eye area; helping improve hyperpigmentation, crepey texture and puffiness… all without the heaviness of filler, or unwanted volume.

Can Polynucleotides Go Wrong?

As with any injectable, technique and experience matter. At Cosmetica London, all treatments are performed by highly trained medical professionals – minimising risks and ensuring optimal results. But generally speaking, this treatment is extremely safe and well tolerated; with long-lasting results that improve over time.

Are Polynucleotides Better Than Profhilo?

They’re not better than one another: they’re different! While Profhilo delivers a surge of hydration, polynucleotides go deeper, encouraging cellular repair and regeneration. Many patients benefit from both – often in a complementary treatment plan. We love both.

How Long Do Results From Polynucleotides Last – And When Will I Notice Improvements?

Most patients begin to notice improvements in their skin around 3-4 weeks after their first treatment. This is when the skin regeneration process kicks in – so you might see a healthier glow, improved hydration and softening of fine lines. Full results typically develop gradually over 2-3 months, especially after completing the recommended course of treatments (usually 2-3 sessions, spaced a few weeks apart). Because polynucleotides stimulate your skin to repair and rebuild itself, this is a long-term investment in skin health rather than a quick fix.

Results can last around 6-9 months, depending on your skin condition, lifestyle and the area treated. Maintenance treatments every 6 months are often recommended to prolong and enhance the benefits.

Ready to discover what regenerative injectables can do for your skin? Book a consultation with our expert team at Cosmetica London and we’ll tailor a plan to your unique skin concerns using the safest, most advanced technology on the market.