JULÄINE Collagen Biostimulator

A next-generation injectable that works with your skin’s own biology – gradually stimulating collagen production to improve firmness, skin quality and the appearance of lines and folds, with results that build naturally over time.

Skin that improves from the inside out

As we age, collagen production slows. The structural support that keeps skin firm, smooth and well-defined gradually diminishes – and no moisturiser or serum can fully replace what is lost from within.

Juläine takes a different approach. Rather than adding volume or masking change, it works by reactivating the skin’s own collagen-producing cells – the fibroblasts – using poly-L-lactic acid (PLLA) microspheres. The result is gradual, sustained improvement in skin quality, firmness and structure that continues to develop over the weeks and months following treatment.

At Cosmetica, Juläine sits at the heart of our regenerative approach. Dr Mica Engel describes it as part of her current ‘dream trio’ for skin quality – alongside Profhilo and WOW Fusion – because it addresses what she values most: not simply changing appearance but helping the skin function better and age more gracefully over time.

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Treatment overview

Treatment type: PLLA collagen biostimulator (non-filler)
Sessions: course of 3, spaced 4–8 weeks apart
Results: gradual improvement from 4–6 weeks; continue for up to 6 months
Duration: up to 2 years with appropriate maintenance
Downtime: minimal – redness and swelling at injection points for 24–48 hours
Suitable for: face, neck, décolleté

What is Juläine and how does it work?

Juläine is a PLLA-based injectable manufactured in Sweden, using LASYNPRO technology – a proprietary process producing highly uniform, biocompatible PLLA microspheres. When injected into the dermis, these microspheres are gradually absorbed by the body. During this process, they stimulate a controlled fibroblast response – triggering the skin’s own collagen-producing cells to increase their activity.

This is fundamentally different from hyaluronic acid treatments like Profhilo or dermal fillers, which work by adding hydration or volume directly. The collagen produced in response to Juläine is your own – genuine new collagen fibres that improve tissue integrity, firmness and skin structure. Results are progressive and look natural.

What to expect

Before your treatment: All Juläine treatments begin with a consultation. We assess your skin, discuss your concerns and confirm whether Juläine is the right option – or whether a different treatment or combination approach would serve you better.

During treatment: Juläine is injected into the target areas using a fine needle. The product is reconstituted with an anaesthetic solution before injection. A typical session takes 30 to 45 minutes.

After treatment: Mild swelling, redness and tenderness is normal and settles within 24 to 48 hours. Results begin to emerge from around four to six weeks after the first session and continue to develop throughout the course.

Is Juläine right for you?

Juläine works particularly well for patients who:

Notice a gradual loss of firmness, definition or skin quality in the face or neck
Want sustained, progressive improvement rather than an immediate visible change
Prefer not to add significant volume – Juläine does not bulk or alter facial proportions
Are aged 30 and above, taking a longer-term regenerative approach to skin health
Want to complement existing treatments such as Profhilo, fillers or anti-wrinkle injections

Book your Juläine consultation

Juläine at Cosmetica London is performed by Dr Mica Engel and Dr Asha Chhaya. Book your treatment today of if unsure if this is the right injectable for you then book a consultation and we will assess your skin, answer your questions and put together a treatment plan for your goals and timeline.